Ret Proto-Oncogene 抗体
Quick Overview for Ret Proto-Oncogene 抗体 (ABIN7670736)
抗原
See all Ret Proto-Oncogene (RET) 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- RET Polyclonal Antibody(Capture/Detector)
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纯化方法
- Antigen Affinity Purification
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免疫原
- Recombinant Human RET protein expressed by Mammalian
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亚型
- IgG
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应用备注
- ELISA Capture 2-8 μg/mL,ELISA Detector 0.1-0.4 μg/mL
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Sterile PBS , pH 7.4
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储存液
- Without preservative
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注意事项
- Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C Valid for 1 month or -20°C Valid for 12 months
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有效期
- 12 months
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- Ret Proto-Oncogene (RET)
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别名
- RET
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背景
- Proto-oncogene tyrosine-protein kinase receptor Ret,Cadherin family member 12,Proto-oncogene c-Ret,This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. RET (Ret Proto-Oncogene) is a Protein Coding gene. Diseases associated with RET include Multiple Endocrine Neoplasia Iia and Medullary Thyroid Carcinoma, Familial. Among its related pathways are RET signaling and Innate Immune System. GO annotations related to this gene include calcium ion binding and protein kinase activity. An important paralog of this gene is PDGFRB.
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UniProt
- P07949
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途径
- RTK signaling, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation
抗原
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